By Mordecai P. Blaustein (auth.), Lucio Annunziato (eds.)

This booklet experiences the textual content of the lectures of the 6th foreign convention on Sodium Calcium trade held in Lacco Ameno within the Island of Ischia within the Gulf of Naples, Italy, from October 1 to October five, 2011.

The current e-book uncovers the main awesome new findings on NCX that emerged because the prior convention on Sodium Calcium trade, akin to the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic legislation of ncx1 gene, the molecular id of the mitochondrial Sodium Calcium Exchanger, and the invention of NCX in unforeseen anatomical destinations resembling the feminine reproductive tract.

The booklet is equipped into eleven elements protecting NCX structural elements, genetic and epigenetic rules, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative illnesses and in immune rules, and the position of the cardiovascular and endocrine structures, in addition to diabetes in body structure and pathophysiology. chosen chapters of the ebook also are dedicated to the interplay of NCKX and different ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

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Extra info for Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange

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William Withering, “An Account of the Foxglove and Some of its Medical Uses” Birmingham, England, July 1, 1785. Acknowledgments I thank Suzanne Ventura for assistance with the manuscript. Supported by NIH/NHLB, NCX. Supported by NIH/NHLBI grants HL-045215, HL-078870, and HL-107555 and NIH/NINDS grant NS-16106. References J. Altamirano, Y. Li, J. DeSantiago, V. R. M. Bers, The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. J. Physiol. 575, 845–854 (2006) A.

Blaustein, Local subplasma membrane Ca2+ signals detected by a tethered Ca2+ sensor. Proc. Natl. Acad. Sci. U. S. A. 103, 13232–13237 (2006) L. Lencesova, A. G. J. P. Blaustein, Plasma membrane- cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes. J. Biol. Chem. 279, 2885–2893 (2004) J. J. Xie, The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking. Biochim. Biophys. Acta 1802, 1237–1245 (2010) L.

Natl. Acad. Sci. U. S. A. 90, 3870–3874 (1993) S. A. V. O. N.

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