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Extra info for Inhaled Particles VI. Proceedings of an International Symposium and Workshop on Lung Dosimetry Organised by the British Occupational Hygiene Society in Co-Operation with the Commission of the European Communities, Cambridge, 2–6 September 1985

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Even on a 1 litre inhalation we cannot just assume that aerosol penetrates uniformly into all regions of the lung. I think that with the one litre inhalation, you probably do get some penetration into the dependent regions of the lung where the aerosol penetrates more deeply. So I think we have a mixed system of airways and airspaces in which Dr. Heyder's most recent approach of using a bolus technique can probably help to clarify some of the questions that we have. J. GEBHART: In response to Dr.

For smokers MEAD vs. MLI was not significant. However, when a multiple regression of these parameters with DSA r as the second predictor was performed, the relationship became highly significant. 7%). A simple linear relationship of MEAD to MLI was seen in the nonsmokers as the best fit function, while for the smokers the best fit was MEAD vs. 2%). DISCUSSION Comparisons of Aerosol Probe and Morphometric Data in Excised Human Lungs: The general similarity in dimensions and their variability by morphometric and aerosol techniques supports the hypothesis that the aerosol probe technique is actually measuring the average sizes of the spaces in these regions.

G E B H A R T , J. H E Y D E R , G . R U D O L F a n d W . , Paul-Ehrlich-Str. 20, D-6000 Frankfurt/Main. 08 //m size range was investigated for a variety of breathing patterns during steady state mouth- and nose breathing. The evaluation of deposition was based upon measurements of mean particle number concentration in inspired and expired air by means of a condensation nucleus counter. Owing to the diffusional particle transport, total deposition increases with decreasing particle size and increasing mean residence time of the aerosol in the lungs.

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