By M. Frier, A C Perkins
This article defines the position and scope of nuclear drugs imaging innovations (gamma scintigraphy) in pharmaceutical examine, giving info from medical trial facts.
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Extra info for Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)
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However, even the use of comparatively simple equipment raises a number of important GMP principles. Cleaning, particularly of the drill bit, is crucial, firstly to prevent contamination of the tablets, secondly to avoid cross-contamination, and thirdly to ensure reproducibility of hole size and prevent tablet cracking by avoiding build-up of film coat residues on the bit. Choice of cleaning agent is also important, both in being effective, and in leaving no residues. Any required lubrication of the drill motor should be performed with approved lubricants.
1987, Radiolabelling of intact dosage forms by neutron activation: effects on in vitro performance, Pharmaceutical Research, 4, 526–528. P. , 1997, Evaluation of gastro-resistant pulsed release delivery system (Pulsincap) in humans, Drug Delivery, 4, 201–206. 1 Introduction Radionuclide imaging has a well-established role in the development and evaluation of products for drug delivery to the respiratory tract. The principal application is in monitoring lung deposition of inhaled aerosols. Radiolabelling of the aerosol allows quantification of the distribution of the formulation.
In this way PET imaging has provided some of the fundamental scientific information relating Instrumentation, Imaging, Data Analysis and Display 27 to the understanding of human physiology. , 1996). 9 Image Processing and Data Analysis Once the images have been stored by computer mathematical operations may be performed to improve the visualization of the data (Sampson, 1994). Simple transformations include windowing the display threshold (lower) and saturation (upper) levels and image smoothing using filters to extract features from the images.
