By Carsten Nieder, Johannes Langendijk

New advancements equivalent to sophisticated mixed modality techniques and important technical advances in radiation remedy making plans and supply are facilitating the re-irradiation of formerly uncovered volumes. consequently, either palliative and healing ways may be pursued at quite a few affliction websites. Re-irradiation: New Frontiers is the 1st ebook to supply a accomplished evaluate on present re-irradiation options. Re-irradiation equipment, technical facets, the function of mixed remedy with anticancer medicinal drugs and hyperthermia, and general tissue tolerance are all mentioned intimately. additionally, disease-specific chapters rfile contemporary scientific effects and destiny examine instructions. execs concerned about radiation therapy making plans and multimodal oncology therapy will locate this publication to be a useful reduction in knowing the advantages and obstacles of re-irradiation and in designing potential trials.

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Extra resources for Re-irradiation: New Frontiers

Sample text

When calculating the BED of the first irradiation course, one has to keep in mind that two opposing fields were used resulting in a maximum dose to parts of the bowel of 105% of the prescribed dose, which was 3 Gy. 15 Gy. We will use an alpha/beta value of 3 Gy in this example. 15 9 (1 ? , 84 Gy3, according to the formula n 9 d 9 (1 ? d 7 alpha/beta value) where n is the number of fractions, and d the dose per fraction. This dose is actually equivalent to 50 Gy in 25 fractions of 2 Gy (BED 83 Gy3).

Head and Neck Cancer ............................................. Cervical Cancer ......................................................... 31 31 32 33 34 4 Summary................................................................... 34 References.......................................................................... 34 Quality-assured local and regional hyperthermia procedures have been proven to enhance the clinical benefits of oncological standard treatments in several clinical settings without a substantial increase of late toxicity.

J Clin Oncol 28:3048–3053 Fu KK, Newman H, Phillips TL (1975) Treatment of locally recurrent carcinoma of the nasopharynx. Radiology 117:425–431 Fu KK, Pajak TF, Trotti A et al (2000) A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7–16 Greenberg M, Eisert DR, Cox JD (1976) Initial evaluation of reduced fractionation in the irradiation of malignant epithelial tumors.

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