By Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul Okunieff

This quantity is predicated at the LENT V NCI-sponsored assembly held in may perhaps 2004 and the CURED I convention in 2006. Written by means of specialists within the box, it addresses a severe themes when it comes to past due results, reminiscent of mechanisms of harm, the function of screening, concepts for interventions, moment malignancies, and prevention. it really is was hoping that those findings may help readers to avoid and deal with the long term side-effects of irradiation.

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References 1. Bagshaw MA, Kallman RF, Rubin P (1985) In memoriam. Henry Seymour Kaplan. Int J Radiat Oncol Biol Phys 11:1–3 2. Kaplan HS, Bagshaw MA (1957) The Stanford medical linear accelerator. III. Application to clinical problems of radiation therapy. Stanford Med Bull 15:141–151 3. Ginzton EL, Nunan CS (1985) History of microwave electron linear accelerators for radiotherapy. Int J Radiat Oncol Biol Phys 11:205–216 4. Rosenberg SA, Kaplan HS (1985) The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984.

Radiat Res 124:43–49 6. Grove AD, Prabhu VV, Young BL et al (2002) Both protein activation and gene expression are involved in early vascular tube formation in vitro. Clin Cancer Res 8:3019– 3026 7. Haimovitz-Friedman A, Fuks Z (1998) Signaling in the radiation response of endothelial cells. In: Rubin DB (ed) The radiation biology of the vascular endothelium. CRC Press, Boca Raton, pp 101–127 8. Johnson LK, Longenecker JP, Fajardo LF (1982) Differential radiation response of cultured endothelial cells and smooth myocytes.

Metz JM, Smith D, Mick R et al (2004) A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Clin Cancer Res 10:6411– 6417 39. Moulder JE, Fish BL, Cohen EP (2003) ACE inhibitors and AII receptor antagonists in the treatment and prevention of bone marrow transplant nephropathy. Curr Pharm Des 9:737–749 40. Moulder JE (2004) Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review.

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