By Jeffrey Raizer, Andrew Parsa

This booklet studies the numerous advances in our figuring out of glioma biology which were completed in the past decade and describes intimately the ensuing new ways to therapy. advancements in surgical recommendations, radiation remedy, and chemotherapy are comprehensively lined, with dialogue in their effect in reducing sufferer morbidity and extending survival. additionally, person chapters are committed in particular to present therapy for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. different issues addressed contain remedy of the aged sufferer, investigating rising remedies from small molecules to immunotherapy and palliative care. This well timed booklet should be a worthwhile resource of up to date info for practitioners and also will be of curiosity to researchers.

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Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, AyersRingler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C (2011) Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328–340. 011 73. Taal W, Dubbink HJ, Zonnenberg CB, Zonnenberg BA, Postma TJ, Gijtenbeek JM, Boogerd W, Groenendijk FH, Kros JM, Kouwenhoven MC, van Marion R, van Heuvel I, van der Holt B, Bromberg JE, Sillevis Smitt PA, Dinjens WN, van den Bent MJ (2011) First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.

Cancer Sci 103(2):269–273. x 69. Sonoda Y, Kumabe T, Nakamura T, Saito R, Kanamori M, Yamashita Y, Suzuki H, Tominaga T (2009) Analysis of IDH1 and IDH2 mutations in Japanese glioma patients. x 70. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial.

With the exception of motor mapping, which can be performed with the patient under general anesthesia, these surgeries are performed under awake conditions. It is our tradition to also perform motor mapping in the awake state, as the efficiency and fidelity of the motor map are improved with the patient under local anesthesia. Patients with less than antigravity strength (0–2/5) or with significant preoperative language deficits (>25 % error rate) that do not improve with short-course steroids may not be good candidates for mapping.

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