By K.S. Clifford Chao MD, Carlos A. Perez MD, Luther W. Brady MD
Washington Univ., St. Louis, MO. handbook for college kids, citizens, and practitioners in radiation oncology. Designed to enrich complete textbooks. comprises up-to-date content material, a brand new bankruptcy on IMRT, and new colour illustrations and computer-generated drawings. prior version: c1999. Softcover. DNLM: Neoplasms--radiotherapy--Handbooks.
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Example text
The less toxic plan is not obvious. (From Lawrence TS, Kessler ML, Ten Haken RK. Clinical interpretation of dose-volume histograms: the basis for normal tissue preservation and tumor dose escalation. In: Meyer JL, Purdy JA, eds. Frontiers of radiation therapy oncology, vol 29, 3-D conformal radiotherapy. ) View Figure Biologic Models • • Because 3-D CRT plans provide both dose and volume information, the traditional practice of determining the "best plan" is extremely difficult (9,21). For example, it is not clear which degree of dose uniformity in the PTV can be tolerated as dose levels are escalated using 3-D CRT, or how high of a dose can be tolerated by a small portion of a normal structure.
Risk of growth retardation is smaller than in the embryonic stage. For doses higher than 1 Gy, there is a risk of sterility and a continuing risk (presumably with no threshold) for a subsequent cancer. Midfetal: 105 to 175 days PC: Irradiation during this period is not likely to induce gross malformations. 65 Gy among persons irradiated in utero during the atom bombing. 5 Gy. There is a continuing risk of subsequent cancer development. Late fetal: more than 175 days PC: Risks of malformation and mental retardation are negligible.
E is the most probable energy of the electron beam at the patient surface. The depth of the 80% depth-dose line is given approximately by E/3 cm. Skin-surface percent depth doses range from approximately 80% for low-energy electrons to 93% for 18-MeV electrons, as shown in Table 3-1. 5 as energy goes from 16 MeV up to 20 MeV). The region of uniform maximum dose is narrow for low-energy electrons and broad for high-energy electrons. The rate of decrease in percent depth dose versus depth, between the 80% and 20% level, is greater for small field sizes than for large field sizes, and greater for lowenergy electrons than high-energy electrons.
