By G.M. Thomas
Even though experimental and medical melanoma learn have to be heavily associated, advances on the simple point frequently stay distant from clinical program. This magazine works to speed up the interpretation of experimental effects to the health center. In each one factor, findings from simple study are built-in with present theoretical wisdom and mentioned by way of their relevance to the detection and remedy of melanoma. major scientific stories from melanoma centres around the globe are integrated, supplemented by way of occasional case experiences and experiences. This identify examines evolving techniques to enhance results and reduce toxicities in radiation remedy.
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Extra info for Evolving Approaches to Improve Outcomes and Minimize Toxicities in Radiation Therapy (Oncology)
Example text
Int J Radiat Oncol Biol Phys 1988;14:831–838. 21 Nordsmark M, Overgaard M, Overgaard J: Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 1996; 41:31–39. 22 Höckel M, Vaupel P: Biological consequences of tumor hypoxia. Semin Oncol 2001;28(suppl 8):36–41. 23 Hlatky L, Tsionou C, Hahnfeldt P, Coleman CN: Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.
All of these approaches combined will slowly but surely contribute towards improving the survival of many patients with locally advanced solid tumors. References 1 Dillman RO, Herndon J, Seagren SL, Eaton WL Jr, Green MR: Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8344 trial. J Natl Cancer Inst 1996; 88:1210–1215. Update on Chemoradiation Trials in Solid Tumors 2 Sause W, Kolesar P, Taylor S IV, Johnson D, Livingston R, Komaki R, Emami B, Curran WJ Jr, Byhardt R, Dar AR, Turrisi A III: Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer.
These include technical improvements in patient selection and staging, which involves the use of ever-improving imaging techniques, radiotherapy sequencing and fractionation, image guidance during RT procedures, brachytherapy, the provision of high radiation doses directly to a tumor through the implantation of small radioactive seeds or sources, radiation intensity modulation, and radiation dose escalation. Until 2000, standard treatment for stage III unresected non-small-cell lung cancer has been sequential chemotherapy and radiation.
